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KMID : 0380620160480010086
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Korean Journal of Food Science and Technology
2016 Volume.48 No. 1 p.86 ~ p.91
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Effects of Opuntia ficus-indica var. saboten Ripe Fruits on Protection of Neuronal PC-12 Cells and Cholinesterase Inhibition
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Hwang Jeong-Seung
Im Sung-bin
Lee In-il
Kim Tae-Rahk
Kim Dae-Ok
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Abstract
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Oxidative stress caused by reactive oxygen species is ascribed to many neurodegenerative diseases like Alzheimer’s disease. Phenolic antioxidants can reduce the oxidative stress. In this study, ripe fruits of Opuntia ficus-indica var. saboten (OFS) were extracted using 80% (v/v) aqueous ethanol. Total phenolic and flavonoid contents of the OFS fruits (100 g) were 409.9 mg gallic acid equivalents and 72.2 mg catechin equivalents, respectively. The OFS fruits had antioxidant capacity at 381.2, 298.2, and 3,219.9 mg vitamin C equivalents/100 g in ABTS, DPPH, and ORAC assays, respectively. The OFS fruits showed protective effects on PC-12 cells against oxidative stress in a dose-dependent manner, partly due to decrease of intracellular oxidative stress. Furthermore, the OFS fruits inhibited both acetylcholinesterase and butyrylcholinesterase. Consequently, these results suggest that the OFS fruits might be served as a source of functional materials to reduce oxidative stress in neuronal cells and to inhibit cholinesterases.
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KEYWORD
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acetylcholinesterase, Opuntia ficus-indica var. saboten, oxidative stress, total phenolic compound, vitamin C equivalent
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